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Campus where you would like to present
SURC Room 140
Start Date
15-5-2014
End Date
15-5-2014
Keywords
Protease-inhibitors, Borinic Acids, Antiretroviral drugs"
Abstract
Approximately 34 million people are currently infected with HIV. The only treatment available involves slowing the development of HIV into AIDS, which is done with a cocktail of antiretroviral drugs such as protease inhibitors. This approach is necessary as the virus continually mutates and develops resistance. Further issues arise from the drugs’ low bioavailability, and high toxicity. To circumvent these obstacles, the goal of this research is to develop a synthesis for a potential HIV-1 protease inhibitor. This inhibitor mimics the transition state of the natural substrate, and it interferes with the viral life cycle. Several linear boron modified peptides will be synthesized in the hopes that the analogs will demonstrate a greater inhibitory activity than their non-boronated counterparts
Recommended Citation
Contreras, Erik, "Synthesis Towards Straight Chain Borinic Acids as Potential HIV-1 Protease Inhibitors" (2014). Symposium Of University Research and Creative Expression (SOURCE). 102.
https://digitalcommons.cwu.edu/source/2014/oralpresentations/102
Additional Mentoring Department
Chemistry
Synthesis Towards Straight Chain Borinic Acids as Potential HIV-1 Protease Inhibitors
SURC Room 140
Approximately 34 million people are currently infected with HIV. The only treatment available involves slowing the development of HIV into AIDS, which is done with a cocktail of antiretroviral drugs such as protease inhibitors. This approach is necessary as the virus continually mutates and develops resistance. Further issues arise from the drugs’ low bioavailability, and high toxicity. To circumvent these obstacles, the goal of this research is to develop a synthesis for a potential HIV-1 protease inhibitor. This inhibitor mimics the transition state of the natural substrate, and it interferes with the viral life cycle. Several linear boron modified peptides will be synthesized in the hopes that the analogs will demonstrate a greater inhibitory activity than their non-boronated counterparts
Faculty Mentor(s)
Fabry-Azstalos, Levente Fabry-Azstalos