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Campus where you would like to present
SURC Room 140
Start Date
15-5-2014
End Date
15-5-2014
Keywords
Pharmaceutical Anthrax Chemistry
Abstract
The bacterium Bacillus anthracis is responsible for the anthrax infection and secretes a toxin composed of three proteins: lethal factor (LF), edema factor (EM), and protective antigen (PA). These toxins persist even if treatment of the bacterial infection takes place and presents a limited window of opportunity for current toxin inhibitors to be administered before widespread necrosis of tissue occurs. Therefore, there is a need for new immediate acting toxin inhibitors. This research is centered on organoboron chemistry for expansion of potential new treatments against acute infection from the biological warfare agent anthrax. This research also illustrates the potential of boron compounds for other medicinal uses and outlines the synthetic versatility of organoboron chemistry. Three novel potential anthrax LF inhibitors will be synthesized. The proposed target compounds will potentially serve as a more effective treatment to toxin damage caused by Bacillus anthracis infection
Recommended Citation
Frank, Michael, "Synthetic Versatility of Boron: Novel Potential Anthrax Lethal Factor Metalloenzyme Inhibitors and Boron Amino Acid Analogs" (2014). Symposium Of University Research and Creative Expression (SOURCE). 119.
https://digitalcommons.cwu.edu/source/2014/oralpresentations/119
Additional Mentoring Department
Chemistry
Synthetic Versatility of Boron: Novel Potential Anthrax Lethal Factor Metalloenzyme Inhibitors and Boron Amino Acid Analogs
SURC Room 140
The bacterium Bacillus anthracis is responsible for the anthrax infection and secretes a toxin composed of three proteins: lethal factor (LF), edema factor (EM), and protective antigen (PA). These toxins persist even if treatment of the bacterial infection takes place and presents a limited window of opportunity for current toxin inhibitors to be administered before widespread necrosis of tissue occurs. Therefore, there is a need for new immediate acting toxin inhibitors. This research is centered on organoboron chemistry for expansion of potential new treatments against acute infection from the biological warfare agent anthrax. This research also illustrates the potential of boron compounds for other medicinal uses and outlines the synthetic versatility of organoboron chemistry. Three novel potential anthrax LF inhibitors will be synthesized. The proposed target compounds will potentially serve as a more effective treatment to toxin damage caused by Bacillus anthracis infection
Faculty Mentor(s)
Fabry-Asztalos, Levente