Synthesis and Testing of Possible Antimicrobial Agents from Breakdown Products of Lasalocid A
Document Type
Oral Presentation
Campus where you would like to present
SURC Ballroom B/C/D
Start Date
21-5-2015
End Date
21-5-2015
Keywords
Antibiotic, Synthesis, Staphylococcus aureus
Abstract
Increased antibiotic resistance has led to increased demand for new antibiotic development. Completely synthetic libraries currently in production lack much of the structural complexity necessary for biological activity. This research focuses on the synthesis of natural product-like compound libraries. The products are derived from lasalocid, a naturally produced antibiotic primarily, used as an additive in cow feed. This parent material was selected for its large degree of structural complexity. A Baeyer-Villiger oxidation will be performed to isolate the most complex portion of the molecule. The functionality of this core scaffold will then be chemically modified. The resulting chemical products will then be tested for antibiotic activity against several pathogenic bacteria including Staphylococcus aureus, the Gram-positive bacterial species responsible for staph infections, using a Kirby-Bauer disk diffusion assay.
Recommended Citation
Wilson, Parker; Handley, Alex; and Baluca, Diana, "Synthesis and Testing of Possible Antimicrobial Agents from Breakdown Products of Lasalocid A" (2015). Symposium Of University Research and Creative Expression (SOURCE). 26.
https://digitalcommons.cwu.edu/source/2015/posters/26
Poster Number
33
Department/Program
Chemistry
Additional Mentoring Department
Chemistry
Synthesis and Testing of Possible Antimicrobial Agents from Breakdown Products of Lasalocid A
SURC Ballroom B/C/D
Increased antibiotic resistance has led to increased demand for new antibiotic development. Completely synthetic libraries currently in production lack much of the structural complexity necessary for biological activity. This research focuses on the synthesis of natural product-like compound libraries. The products are derived from lasalocid, a naturally produced antibiotic primarily, used as an additive in cow feed. This parent material was selected for its large degree of structural complexity. A Baeyer-Villiger oxidation will be performed to isolate the most complex portion of the molecule. The functionality of this core scaffold will then be chemically modified. The resulting chemical products will then be tested for antibiotic activity against several pathogenic bacteria including Staphylococcus aureus, the Gram-positive bacterial species responsible for staph infections, using a Kirby-Bauer disk diffusion assay.
Faculty Mentor(s)
P. Whitney Swain