Title

Evaluation of the Anthelmintic Activity of Plant Extracts on the Hookworm Ancylostoma ceylanicum

Presenter Information

Brianda Cardenas-Garcia

Document Type

Oral Presentation

Location

SURC Ballroom B/C/D

Start Date

21-5-2015

End Date

21-5-2015

Keywords

Parasite, Hookworm, Plants

Abstract

Hookworm is among the most common and important tropical diseases in the world. This parasitic nematode feeds on human blood upon reaching the small intestine. Previous studies have confirmed resistance to available drugs, rendering it necessary to develop new treatments. Although necessary, research and production of possible treatments has been neglected in the past because drug development for impoverished areas does not result in a sufficient amount of profit. Earlier projects within Dr. Blaise Dondji’s lab have shown that plant natural products cause mortality of adult hookworm ex vivo. The plants Dalea ornata, Oemlaria cerasiformis, and Eucalyptus globulus have already shown efficacy; adult worms have demonstrated either significant decreases in motility or an increase in mortality. Now, the active components of the plants extracts that are effective must be identified. The goal of this project is to assess the anthelminthic effects of natural plant extracts for activity against Ancylostoma ceylanicum in the animal model host, the Syrian hamster (Mesocricetus auratus). If an effective fraction is discovered, identifying the active ingredients of the fraction and testing their anthelminthic effects can help develop new potential control tools to help reduce the health burden that results from soil-transmitted nematodes such as Ancylostoma ceylanicum.

Poster Number

49

Faculty Mentor(s)

Blaise Dondji

Department/Program

Biological Sciences

Additional Mentoring Department

Biological Sciences

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Evaluation of the Anthelmintic Activity of Plant Extracts on the Hookworm Ancylostoma ceylanicum

SURC Ballroom B/C/D

Hookworm is among the most common and important tropical diseases in the world. This parasitic nematode feeds on human blood upon reaching the small intestine. Previous studies have confirmed resistance to available drugs, rendering it necessary to develop new treatments. Although necessary, research and production of possible treatments has been neglected in the past because drug development for impoverished areas does not result in a sufficient amount of profit. Earlier projects within Dr. Blaise Dondji’s lab have shown that plant natural products cause mortality of adult hookworm ex vivo. The plants Dalea ornata, Oemlaria cerasiformis, and Eucalyptus globulus have already shown efficacy; adult worms have demonstrated either significant decreases in motility or an increase in mortality. Now, the active components of the plants extracts that are effective must be identified. The goal of this project is to assess the anthelminthic effects of natural plant extracts for activity against Ancylostoma ceylanicum in the animal model host, the Syrian hamster (Mesocricetus auratus). If an effective fraction is discovered, identifying the active ingredients of the fraction and testing their anthelminthic effects can help develop new potential control tools to help reduce the health burden that results from soil-transmitted nematodes such as Ancylostoma ceylanicum.