Title

One-shot access to isoquinolone and (hetero)izidinone architectures using cyclic α-chloro eneformamides and cyclic anhydrides

Authors

Timothy K. Beng, Central Washington UniversityFollow
Spencer Langevin, Central Washington University
Abdikani Omar Farah, Central Washington University
Joshua Goodsell, Central Washington University
Katie Wyatt, Central Washington University

Document Type

Article

Department or Administrative Unit

Chemistry

Publication Date

3-18-2019

Abstract

Functionalized izidinones and isoquinolones are commonplace motifs in bioactive molecules. Here, we describe a direct and modular approach to [6,n] and [7,n]-1-azabicyclic unsaturated lactams, most of which bear at least one endocyclic heteroatom. A site-selective hexannulation reaction between cyclic α-chloro eneformamides and cyclic anhydrides is implicated. The scope of the anhydride component in a Castagnoli–Cushman reaction has been extended beyond 5-, 6-, and 7-membered rings.

Comments

This article was originally published in New Journal of Chemistry. The full-text article from the publisher can be found here.

Due to copyright restrictions, this article is not available for free download from ScholarWorks @ CWU.

Recommended Citation

Beng, T. K., Langevin, S., Farah, A. O., Goodsell, J., & Wyatt, K. (2019). One-shot access to isoquinolone and (hetero)izidinone architectures using cyclic α-chloro eneformamides and cyclic anhydrides. New Journal of Chemistry, 43(14), 5282–5286. https://doi.org/10.1039/c8nj06539j

Journal

New Journal of Chemistry