One-shot access to isoquinolone and (hetero)izidinone architectures using cyclic α-chloro eneformamides and cyclic anhydrides
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Functionalized izidinones and isoquinolones are commonplace motifs in bioactive molecules. Here, we describe a direct and modular approach to [6,n] and [7,n]-1-azabicyclic unsaturated lactams, most of which bear at least one endocyclic heteroatom. A site-selective hexannulation reaction between cyclic α-chloro eneformamides and cyclic anhydrides is implicated. The scope of the anhydride component in a Castagnoli–Cushman reaction has been extended beyond 5-, 6-, and 7-membered rings.
Beng, T. K., Langevin, S., Farah, A. O., Goodsell, J., & Wyatt, K. (2019). One-shot access to isoquinolone and (hetero)izidinone architectures using cyclic α-chloro eneformamides and cyclic anhydrides. New Journal of Chemistry, 43(14), 5282–5286. https://doi.org/10.1039/c8nj06539j
New Journal of Chemistry