Title

Intramolecular Benzylic sp3 C-H Oxy-functionalization of Lactam-bearing Alkanoic Acids

Document Type

Poster

Campus where you would like to present

Ellensburg

Event Website

https://digitalcommons.cwu.edu/source

Start Date

18-5-2020

Abstract

Leishmaniasis is one of the world’s most problematic diseases in developing countries. Current medicines, including the frequently prescribed medicine, amphotericin B, have serious side effects. The existing medicines also exhibit significant parasite resistance problems. In recent years, medicinal chemists have become increasingly keen on exploring the spatial orientation of molecules. Thus, threedimensional N-heterocycles and O- heterocycles (e.g., morpholines, piperazines, and piperidines) are valuable targets for pharmaceutical companies. In this proposal, a chemoselective and stereoselective strategy for the formation of the aforementioned compounds is described. This versatile, efficient, and cost-effective process will take advantage of the more acidic nature of the benzylic carbon. Through collaborative efforts, the leishmanicidal activity of these novel compounds against Leishmania major will be tested.

Faculty Mentor(s)

Timothy Beng

Department/Program

Chemistry

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May 18th, 12:00 PM

Intramolecular Benzylic sp3 C-H Oxy-functionalization of Lactam-bearing Alkanoic Acids

Ellensburg

Leishmaniasis is one of the world’s most problematic diseases in developing countries. Current medicines, including the frequently prescribed medicine, amphotericin B, have serious side effects. The existing medicines also exhibit significant parasite resistance problems. In recent years, medicinal chemists have become increasingly keen on exploring the spatial orientation of molecules. Thus, threedimensional N-heterocycles and O- heterocycles (e.g., morpholines, piperazines, and piperidines) are valuable targets for pharmaceutical companies. In this proposal, a chemoselective and stereoselective strategy for the formation of the aforementioned compounds is described. This versatile, efficient, and cost-effective process will take advantage of the more acidic nature of the benzylic carbon. Through collaborative efforts, the leishmanicidal activity of these novel compounds against Leishmania major will be tested.

https://digitalcommons.cwu.edu/source/2020/COTS/34