Concise total synthesis of phidianidine A and B
Department or Administrative Unit
The shortest total synthesis of cytotoxic indole alkaloids phidianidine A and B is described. Rapid assembly of the 1,2,4-oxadiazole core from a novel N-hydroxyguanidine and the corresponding indole-3-acetic acid chloride led to formal syntheses of phidianidine A and B in only three steps from known compounds. Deprotection under standard conditions provided the trifluoroacetate salts of phidianidine A and B in quantitative yield.
Buchanan, J. C., Petersen, B. P., & Chamberland, S. (2013). Concise total synthesis of phidianidine A and B. Tetrahedron Letters, 54(45), 6002–6004. https://doi.org/10.1016/j.tetlet.2013.08.063
Copyright © 2013 Elsevier Ltd. All rights reserved.