Title
Concise total synthesis of phidianidine A and B
Document Type
Article
Department or Administrative Unit
Chemistry
Publication Date
11-6-2013
Abstract
The shortest total synthesis of cytotoxic indole alkaloids phidianidine A and B is described. Rapid assembly of the 1,2,4-oxadiazole core from a novel N-hydroxyguanidine and the corresponding indole-3-acetic acid chloride led to formal syntheses of phidianidine A and B in only three steps from known compounds. Deprotection under standard conditions provided the trifluoroacetate salts of phidianidine A and B in quantitative yield.
Recommended Citation
Buchanan, J. C., Petersen, B. P., & Chamberland, S. (2013). Concise total synthesis of phidianidine A and B. Tetrahedron Letters, 54(45), 6002–6004. https://doi.org/10.1016/j.tetlet.2013.08.063
Journal
Tetrahedron Letters
Rights
Copyright © 2013 Elsevier Ltd. All rights reserved.
Comments
This article was originally published in Tetrahedron Letters. The full-text article from the publisher can be found here.
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