Ultrahigh-Viscosity Hydroxypropylmethylcellulose Blunts Postprandial Glucose after a Breakfast Meal in Women
Department or Administrative Unit
Nutrition Exercise and Health Sciences
Objective: To determine the effects of two water-soluble dietary fibers, ultrahigh-viscosity hydroxypropylmethylcellulose (UHV-HPMC, nonfermentable) and psyllium fiber (fermentable), on postprandial glucose and second meal effects.
Methods: In a single-blind crossover design, 12 healthy adult subjects were given standardized, premeasured breakfast and lunch meals with either 4 g of the fiber supplements or a placebo. Blood glucose was measured with a continuous blood glucose monitoring system (DexCom Seven Plus, San Diego, CA).
Results: Subjects consuming UHV-HPMC had significantly (p < 0.05) lower blood glucose area under the curve (AUC) 2 hours after breakfast than those receiving a placebo. Subjects consuming psyllium also tended to have lower glucose levels than the placebo group. Peak glucose concentration following breakfast was significantly (p < 0.01) less with UHV-HPMC when compared with the placebo. No significant differences in AUC or peak glucose concentration between treatments following the second meal (lunch) were detected, suggesting no residual effect from the fiber supplements.
Conclusions: Supplementation with viscous water-soluble fibers may be an effective means of reducing the glycemic response of a meal in healthy adults.
Dow, S., Pritchett, K. L., Hawk, S., Herrington, S. J., & Gee, D. L. (2012). Ultrahigh-Viscosity Hydroxypropylmethylcellulose Blunts Postprandial Glucose after a Breakfast Meal in Women. Journal of the American College of Nutrition, 31(2), 94–99. https://doi.org/10.1080/07315724.2012.10720014
Journal of the American College of Nutrition