Document Type


Date of Degree Completion

Spring 2022

Degree Name

Master of Science (MS)



Committee Chair

David Gee

Second Committee Member

Susan Hawk

Third Committee Member

Dana Ogan


The aim of this study was to investigate the effects of a history of weight cycling on insulin resistance (IR) utilizing the 2015-2020 NHANES database. A value greater than 3.2 for homeostatic model assessment of insulin resistance (HOMA-IR) was used to define IR. No study to date has examined the weight cycling question since its application in the NHANES 2015-2016 cycle year. RESULTS 53% of the total 4100 participants reported weight cycling at least once and 33% of the total were classified as having IR. Prevalence of IR and obesity were highest amongst those who weight cycled 3 times or more, and diabetics were more likely to weight cycle than non-diabetics. A positive association was found for history of weight cycling and average BMI, maximum historical BMI, waist circumference, HOMA-IR, and fasting insulin levels. Simple logistic regression showed that weight cycling 3 times or more substantially increased the odds of becoming obese (OR 4.42, PP