Title

Two-Step Synthesis of Novel Boronates; Structural Building Blocks of Therapeutically Relevant Compounds

Document Type

Poster

Campus where you would like to present

Ellensburg

Event Website

https://digitalcommons.cwu.edu/source

Start Date

18-5-2020

Abstract

Every year the number of multidrug-resistant bacteria and viruses increases, sparking a tremendous need for the development of more powerful countermeasures. Modification of current drug therapies is a short term solution, but the need for novel medicinal compounds is critical for long term defense. The use of boron-modified compounds (those containing a strategically placed boron atom), as potential antibiotics and antivirals, has been investigated and have shown potential to be powerful therapeutic agents. There are currently three boronmodified FDA approved medications, which indicates that there is tremendous potential for further discovery and development. Currently, the Fabry Research Group focuses its efforts on boron modified inhibitors of HIV-1 aspartic protease. The group’s interest in the broader application of these compounds, however, extends far beyond this single virus. The goal of this project been create a diverse library of functional novel boronate analogues. All of these structures provide potential starting points or building blocks for therapeutic compounds that could aid in the fight against multi-drug resistance. The properties that make boron a powerful addition to inhibitory compounds, also provide difficult synthetic challenges. The synthesis of this novel boronate library will contribute to further understanding some synthetic limitations within boron chemistry. College of the Sciences Presentation Award Winner.

Faculty Mentor(s)

Levente Fabry

Department/Program

Chemistry

Share

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May 18th, 12:00 PM

Two-Step Synthesis of Novel Boronates; Structural Building Blocks of Therapeutically Relevant Compounds

Ellensburg

Every year the number of multidrug-resistant bacteria and viruses increases, sparking a tremendous need for the development of more powerful countermeasures. Modification of current drug therapies is a short term solution, but the need for novel medicinal compounds is critical for long term defense. The use of boron-modified compounds (those containing a strategically placed boron atom), as potential antibiotics and antivirals, has been investigated and have shown potential to be powerful therapeutic agents. There are currently three boronmodified FDA approved medications, which indicates that there is tremendous potential for further discovery and development. Currently, the Fabry Research Group focuses its efforts on boron modified inhibitors of HIV-1 aspartic protease. The group’s interest in the broader application of these compounds, however, extends far beyond this single virus. The goal of this project been create a diverse library of functional novel boronate analogues. All of these structures provide potential starting points or building blocks for therapeutic compounds that could aid in the fight against multi-drug resistance. The properties that make boron a powerful addition to inhibitory compounds, also provide difficult synthetic challenges. The synthesis of this novel boronate library will contribute to further understanding some synthetic limitations within boron chemistry. College of the Sciences Presentation Award Winner.

https://digitalcommons.cwu.edu/source/2020/COTS/41