Charting the Chemical Reactivity Space of Castagnoli-Cushman-Derived N-heterocyclic Sulfones
Document Type
Poster
Campus where you would like to present
Ellensburg
Event Website
https://digitalcommons.cwu.edu/source
Start Date
16-5-2021
End Date
22-5-2021
Keywords
Organic Chemistry, Pharmaceuticals, Synthesis
Abstract
N-heterocyclic sulfones are present in many pharmaceuticals, including antityrpanosomal drug Nifurtimox. There is therefore an increasing demand for methodologies that create N-heterocyclic sulfones. This is all the more necessary since drug-resistance issues continue to persist, and there is a decreasing number of potent compounds isolated from nature that tend to satisfy the demands of high throughput screening. This project has achieved a cheap, site-selective, and orientation-selective protocol for constructing N-heterocyclic sulfones. The novel sp3-enriched compounds have considerable structural diversity. Moreover, the approach is highly modular and afforded highly functionalized N-heterocyclic sulfones bearing synthetically useful functional groups such as alkenes, alkynes, and aldehydes. This library of N-heterocyclic sulfone compounds will undergo structure-activity relationship (SAR) studies via an in-house collaboration with Dr. Dondji, with a focus on neglected tropical diseases. Winner, College of the Sciences Presentation Award.
Recommended Citation
Garcia, Jorge, "Charting the Chemical Reactivity Space of Castagnoli-Cushman-Derived N-heterocyclic Sulfones" (2021). Symposium Of University Research and Creative Expression (SOURCE). 35.
https://digitalcommons.cwu.edu/source/2021/COTS/35
Department/Program
Chemistry
Additional Mentoring Department
https://cwu.studentopportunitycenter.com/charting-the-chemical-reactivity-space-of-castagnoli-cushman-derived-n-heterocyclic-sulfones/
Charting the Chemical Reactivity Space of Castagnoli-Cushman-Derived N-heterocyclic Sulfones
Ellensburg
N-heterocyclic sulfones are present in many pharmaceuticals, including antityrpanosomal drug Nifurtimox. There is therefore an increasing demand for methodologies that create N-heterocyclic sulfones. This is all the more necessary since drug-resistance issues continue to persist, and there is a decreasing number of potent compounds isolated from nature that tend to satisfy the demands of high throughput screening. This project has achieved a cheap, site-selective, and orientation-selective protocol for constructing N-heterocyclic sulfones. The novel sp3-enriched compounds have considerable structural diversity. Moreover, the approach is highly modular and afforded highly functionalized N-heterocyclic sulfones bearing synthetically useful functional groups such as alkenes, alkynes, and aldehydes. This library of N-heterocyclic sulfone compounds will undergo structure-activity relationship (SAR) studies via an in-house collaboration with Dr. Dondji, with a focus on neglected tropical diseases. Winner, College of the Sciences Presentation Award.
https://digitalcommons.cwu.edu/source/2021/COTS/35
Faculty Mentor(s)
Timothy Beng