Copper-catalyzed alkenylation of novel N-iodoarylated allylic ketopiperazinonates with unactivated alkenes

Authors

Timothy K. Beng, Central Washington UniversityFollow
Antonio Moreno, Central Washington University

Document Type

Article

Department or Administrative Unit

Chemistry

Publication Date

2-25-2020

Abstract

N-Aryl-substituted piperazines constitute the core of several pharmacologically pertinent targets such as the antidepressant trintellix. We herein demonstrate that novel N-iodoaryl-substituted allylic ketopiperazinonates are amenable to efficient CuBr-catalyzed alkenylation with simple alkenes to afford N-stilbeno or styrenyl piperazine derivatives.

Comments

This article was originally published in New Journal of Chemistry. The full-text article from the publisher can be found here.

Due to copyright restrictions, this article is not available for free download from ScholarWorks @ CWU.

Recommended Citation

Beng, T. K., & Moreno, A. (2020). Copper-catalyzed alkenylation of novel N-iodoarylated allylic ketopiperazinonates with unactivated alkenes. New Journal of Chemistry, 44(11), 4257–4261. https://doi.org/10.1039/c9nj06178a

Journal

New Journal of Chemistry