Copper-catalyzed alkenylation of novel N-iodoarylated allylic ketopiperazinonates with unactivated alkenes
Department or Administrative Unit
N-Aryl-substituted piperazines constitute the core of several pharmacologically pertinent targets such as the antidepressant trintellix. We herein demonstrate that novel N-iodoaryl-substituted allylic ketopiperazinonates are amenable to efficient CuBr-catalyzed alkenylation with simple alkenes to afford N-stilbeno or styrenyl piperazine derivatives.
Beng, T. K., & Moreno, A. (2020). Copper-catalyzed alkenylation of novel N-iodoarylated allylic ketopiperazinonates with unactivated alkenes. New Journal of Chemistry, 44(11), 4257–4261. https://doi.org/10.1039/c9nj06178a
New Journal of Chemistry
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