Modular access to formamide-tethered α-halo ynones via the deconstructive oxo-halogenation of readily available α-alkynyl eneformamides

Authors

Timothy K. Beng, Central Washington UniversityFollow
Abdikani Omar Farah, Central Washington University

Document Type

Article

Department or Administrative Unit

Chemistry

Publication Date

4-30-2020

Abstract

Herein, we describe a chemoselective, regioselective, modular, and efficient deconstructive oxo-halogenation strategy, which skeletally remodels readily available cyclic α-alkynyl eneformamides into formamide-tethered α-halo ynones. This scaffold-hopping transformation furnishes diverse architectures that would be challenging to achieve through traditional disconnections.

Comments

This article was originally published in Tetrahedron Letters. The full-text article from the publisher can be found here.

Due to copyright restrictions, this article is not available for free download from ScholarWorks @ CWU.

Recommended Citation

Beng, T. K., & Farah, A. O. (2020). Modular access to formamide-tethered α-halo ynones via the deconstructive oxo-halogenation of readily available α-alkynyl eneformamides. Tetrahedron Letters, 61(18), 151821. https://doi.org/10.1016/j.tetlet.2020.151821

Journal

Tetrahedron Letters