Document Type

Thesis

Date of Degree Completion

Winter 1974

Degree Name

Master of Science (MS)

Department

Experimental Psychology

Committee Chair

Terry L. Devietti

Second Committee Member

Vaughn Gerald Reed

Third Committee Member

Robert D. Gaines

Abstract

Two experiments compared the state-dependent effects of electroconvulsive shock (ECS) and physostigmine relative to a normal state (saline or no injection). Rats were trained in a water T maze using a discrimination-training paradigm. In Experiment 1, discrimination was found between the ECS- and normal state. However, response control was strongest in the ECS-0 treatment-training order and on non-ECS training sessions. In Experiment 2, dissociation also occurred but was more pronounced in the P-0 (physostigmine-saline) treatment-training order and on the saline training sessions. Results from both experiments indicate learning is most rapid in the treatment-no treatment training order and that a continuum exists with strong-to-moderate response control occurring in the following order of states: (1) normal, (2) ECS, (3) physostigmine.

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