Off-campus CWU users: To download documents with restricted access, please use your Wildcat Connection username and password to log in after clicking on the link below.
Non-CWU users: Please contact Brooks Library to request access to restricted materials.
Campus where you would like to present
SURC Room 140
Start Date
15-5-2014
End Date
15-5-2014
Keywords
HIV, Inhibitor, Organic Chemistry
Abstract
Drug discovery for HIV/AIDS has resulted in many life-saving therapies, making a great impact on modern medicine. Even though new therapies are constantly being developed, many drugs are highly susceptible to resistance development, have poor bioavailability, and cause several side effects. With that in mind, there is an urgent need for the development of new types of inhibitory compounds that have better resistance profiles, higher bioavailability, higher affinity and lower toxicity. The use of boron in medicinal chemistry has been growing substantially over the last decade since the development of the first FDA approved drug, Velcade, in 2003. Boron containing compounds have been previously overlooked due to preconceived notions regarding boron’s toxicity. With those ideas resolved, boron is being implemented in modern pharmaceutical therapeutics for a variety of diseases. Regarding HIV/AIDS, novel cyclic boronates are currently being synthesized with the intention of acting as dual-mode, both competitive and associative, inhibitors of the HIV-1 protease. The boronated analogues are being synthesized with the intent that they will demonstrate greater inhibitory activity than their non-boronated analogs.
For this presentation, Nicholas Treich received a College of the Sciences Best Oral Presentation Award for 2014.
Recommended Citation
Treich, Nicholas, "Towards the Synthesis of 1,3-Azaborines as Potential HIV-1 Protease Inhibitors" (2014). Symposium Of University Research and Creative Expression (SOURCE). 114.
https://digitalcommons.cwu.edu/source/2014/oralpresentations/114
Additional Mentoring Department
Chemistry
Towards the Synthesis of 1,3-Azaborines as Potential HIV-1 Protease Inhibitors
SURC Room 140
Drug discovery for HIV/AIDS has resulted in many life-saving therapies, making a great impact on modern medicine. Even though new therapies are constantly being developed, many drugs are highly susceptible to resistance development, have poor bioavailability, and cause several side effects. With that in mind, there is an urgent need for the development of new types of inhibitory compounds that have better resistance profiles, higher bioavailability, higher affinity and lower toxicity. The use of boron in medicinal chemistry has been growing substantially over the last decade since the development of the first FDA approved drug, Velcade, in 2003. Boron containing compounds have been previously overlooked due to preconceived notions regarding boron’s toxicity. With those ideas resolved, boron is being implemented in modern pharmaceutical therapeutics for a variety of diseases. Regarding HIV/AIDS, novel cyclic boronates are currently being synthesized with the intention of acting as dual-mode, both competitive and associative, inhibitors of the HIV-1 protease. The boronated analogues are being synthesized with the intent that they will demonstrate greater inhibitory activity than their non-boronated analogs.
For this presentation, Nicholas Treich received a College of the Sciences Best Oral Presentation Award for 2014.
Faculty Mentor(s)
Fabry-Asztalos, Levente