Comparative Study of Periwinkle Extract on MCF-7 Breast Cancer and C2C12 Myoblast Growth Rate and Morphology
Document Type
Oral Presentation
Campus where you would like to present
SURC Ballroom C/D
Start Date
15-5-2014
End Date
15-5-2014
Keywords
Breast cancer, Periwinkle, Neutraceutical
Abstract
Nutritional supplements, or neutraceuticals, are touted by many for their purported ability to maintain wellness and treat disease. Neutraceutical treatment of human diseases is gaining popularity; however comparatively few scientific studies support their routine use. This study compares the effects of periwinkle extract as a neutraceutical treatment to determine if it has a differential impact on cancerous and normal cell lines. Periwinkle, a flower currently used to help treat leukemia and lymphoma, is a prime candidate for study. An exploratory study was conducted to investigate periwinkle’s effect on growth rate and morphology for MCF-7 human breast cancer and C2C12 mouse myoblast cell lines. Initial studies showed a dose-dependent decrease of MCF-7 viability as well as dramatic changes in cancer cell morphology; however periwinkle’s effects on normal cells is unknown. Ideally, periwinkle would differentially affect breast cancer but not normal cells. This ongoing study is investigating that question. Based on preliminary results, we anticipate that: a) MCF-7 human breast cancer cell growth rate will decrease as periwinkle concentration increases; b) MCF-7 morphology will change as periwinkle concentration changes; C2C12 muscle cell viability be unaffected at normal but will decrease at high periwinkle concentrations; and C2C12 muscle cell morphology remain unchanged as periwinkle concentration changes. Forthcoming study results will support or refute our hypotheses.
This presentation received a People's Choice Award for Best Poster Presentation, 2014.
Recommended Citation
Brizendine, Amanda; Heidinger, Brigitta; Tapia, Nancy; and Williams, Carin, "Comparative Study of Periwinkle Extract on MCF-7 Breast Cancer and C2C12 Myoblast Growth Rate and Morphology" (2014). Symposium Of University Research and Creative Expression (SOURCE). 12.
https://digitalcommons.cwu.edu/source/2014/posters/12
Poster Number
20
Additional Mentoring Department
Biological Sciences
Comparative Study of Periwinkle Extract on MCF-7 Breast Cancer and C2C12 Myoblast Growth Rate and Morphology
SURC Ballroom C/D
Nutritional supplements, or neutraceuticals, are touted by many for their purported ability to maintain wellness and treat disease. Neutraceutical treatment of human diseases is gaining popularity; however comparatively few scientific studies support their routine use. This study compares the effects of periwinkle extract as a neutraceutical treatment to determine if it has a differential impact on cancerous and normal cell lines. Periwinkle, a flower currently used to help treat leukemia and lymphoma, is a prime candidate for study. An exploratory study was conducted to investigate periwinkle’s effect on growth rate and morphology for MCF-7 human breast cancer and C2C12 mouse myoblast cell lines. Initial studies showed a dose-dependent decrease of MCF-7 viability as well as dramatic changes in cancer cell morphology; however periwinkle’s effects on normal cells is unknown. Ideally, periwinkle would differentially affect breast cancer but not normal cells. This ongoing study is investigating that question. Based on preliminary results, we anticipate that: a) MCF-7 human breast cancer cell growth rate will decrease as periwinkle concentration increases; b) MCF-7 morphology will change as periwinkle concentration changes; C2C12 muscle cell viability be unaffected at normal but will decrease at high periwinkle concentrations; and C2C12 muscle cell morphology remain unchanged as periwinkle concentration changes. Forthcoming study results will support or refute our hypotheses.
This presentation received a People's Choice Award for Best Poster Presentation, 2014.
Faculty Mentor(s)
Quitadamo, Ian