Evaluation of the toxicity to mammalian cells of plant extracts with anthelminthic activity
Document Type
Oral Presentation
Campus where you would like to present
SURC Ballroom C/D
Start Date
15-5-2014
End Date
15-5-2014
Keywords
Hookworm, Treatments, Toxicity
Abstract
Hookworm infection is one of the most common and important tropical diseases in the world, affecting over 700 million people within impoverished areas worldwide. Frequent deworming with benzimidazoles is the current treatment. However, this method has begun to show resistance, rendering it necessary to develop new treatments. Despite the need, research and production has been essentially neglected for the past three decades because drug development for impoverished areas provides little commercial gain. Within Dr. Blaise Dondji’s lab and in collaboration with Dr. Gil Belofsky, the plants Dalea ornata and Oemlaria cerasiformis have already shown in vitro activity against hookworm, but their toxicity remains to be tested. My current plan will be to test the toxicity of the plants to mammalian cells because they must demonstrate their safety before in vivo testing. Safety will be assessed by measuring the death and efficiency of cell division using C2C12 mouse myoblasts and hamster spleen cells.
Recommended Citation
McCornack, Jocelyn, "Evaluation of the toxicity to mammalian cells of plant extracts with anthelminthic activity" (2014). Symposium Of University Research and Creative Expression (SOURCE). 32.
https://digitalcommons.cwu.edu/source/2014/posters/32
Poster Number
19
Additional Mentoring Department
Biological Sciences
Evaluation of the toxicity to mammalian cells of plant extracts with anthelminthic activity
SURC Ballroom C/D
Hookworm infection is one of the most common and important tropical diseases in the world, affecting over 700 million people within impoverished areas worldwide. Frequent deworming with benzimidazoles is the current treatment. However, this method has begun to show resistance, rendering it necessary to develop new treatments. Despite the need, research and production has been essentially neglected for the past three decades because drug development for impoverished areas provides little commercial gain. Within Dr. Blaise Dondji’s lab and in collaboration with Dr. Gil Belofsky, the plants Dalea ornata and Oemlaria cerasiformis have already shown in vitro activity against hookworm, but their toxicity remains to be tested. My current plan will be to test the toxicity of the plants to mammalian cells because they must demonstrate their safety before in vivo testing. Safety will be assessed by measuring the death and efficiency of cell division using C2C12 mouse myoblasts and hamster spleen cells.
Faculty Mentor(s)
Dondji, Blaise