Evaluation of the Anthelmintic Activity of Plant Extracts on the Hookworm Ancylostoma ceylanicum
Document Type
Oral Presentation
Campus where you would like to present
SURC Ballroom B/C/D
Start Date
21-5-2015
End Date
21-5-2015
Keywords
Parasite, Hookworm, Plants
Abstract
Hookworm is among the most common and important tropical diseases in the world. This parasitic nematode feeds on human blood upon reaching the small intestine. Previous studies have confirmed resistance to available drugs, rendering it necessary to develop new treatments. Although necessary, research and production of possible treatments has been neglected in the past because drug development for impoverished areas does not result in a sufficient amount of profit. Earlier projects within Dr. Blaise Dondji’s lab have shown that plant natural products cause mortality of adult hookworm ex vivo. The plants Dalea ornata, Oemlaria cerasiformis, and Eucalyptus globulus have already shown efficacy; adult worms have demonstrated either significant decreases in motility or an increase in mortality. Now, the active components of the plants extracts that are effective must be identified. The goal of this project is to assess the anthelminthic effects of natural plant extracts for activity against Ancylostoma ceylanicum in the animal model host, the Syrian hamster (Mesocricetus auratus). If an effective fraction is discovered, identifying the active ingredients of the fraction and testing their anthelminthic effects can help develop new potential control tools to help reduce the health burden that results from soil-transmitted nematodes such as Ancylostoma ceylanicum.
Recommended Citation
Cardenas-Garcia, Brianda, "Evaluation of the Anthelmintic Activity of Plant Extracts on the Hookworm Ancylostoma ceylanicum" (2015). Symposium Of University Research and Creative Expression (SOURCE). 39.
https://digitalcommons.cwu.edu/source/2015/posters/39
Poster Number
49
Department/Program
Biological Sciences
Additional Mentoring Department
Biological Sciences
Evaluation of the Anthelmintic Activity of Plant Extracts on the Hookworm Ancylostoma ceylanicum
SURC Ballroom B/C/D
Hookworm is among the most common and important tropical diseases in the world. This parasitic nematode feeds on human blood upon reaching the small intestine. Previous studies have confirmed resistance to available drugs, rendering it necessary to develop new treatments. Although necessary, research and production of possible treatments has been neglected in the past because drug development for impoverished areas does not result in a sufficient amount of profit. Earlier projects within Dr. Blaise Dondji’s lab have shown that plant natural products cause mortality of adult hookworm ex vivo. The plants Dalea ornata, Oemlaria cerasiformis, and Eucalyptus globulus have already shown efficacy; adult worms have demonstrated either significant decreases in motility or an increase in mortality. Now, the active components of the plants extracts that are effective must be identified. The goal of this project is to assess the anthelminthic effects of natural plant extracts for activity against Ancylostoma ceylanicum in the animal model host, the Syrian hamster (Mesocricetus auratus). If an effective fraction is discovered, identifying the active ingredients of the fraction and testing their anthelminthic effects can help develop new potential control tools to help reduce the health burden that results from soil-transmitted nematodes such as Ancylostoma ceylanicum.
Faculty Mentor(s)
Blaise Dondji