Intramolecular Benzylic sp3 C-H Oxy-functionalization of Lactam-bearing Alkanoic Acids
Document Type
Poster
Campus where you would like to present
Ellensburg
Event Website
https://digitalcommons.cwu.edu/source
Start Date
18-5-2020
Abstract
Leishmaniasis is one of the world’s most problematic diseases in developing countries. Current medicines, including the frequently prescribed medicine, amphotericin B, have serious side effects. The existing medicines also exhibit significant parasite resistance problems. In recent years, medicinal chemists have become increasingly keen on exploring the spatial orientation of molecules. Thus, threedimensional N-heterocycles and O- heterocycles (e.g., morpholines, piperazines, and piperidines) are valuable targets for pharmaceutical companies. In this proposal, a chemoselective and stereoselective strategy for the formation of the aforementioned compounds is described. This versatile, efficient, and cost-effective process will take advantage of the more acidic nature of the benzylic carbon. Through collaborative efforts, the leishmanicidal activity of these novel compounds against Leishmania major will be tested.
Recommended Citation
Garcia, Jorge and Smith, Meagan, "Intramolecular Benzylic sp3 C-H Oxy-functionalization of Lactam-bearing Alkanoic Acids" (2020). Symposium Of University Research and Creative Expression (SOURCE). 34.
https://digitalcommons.cwu.edu/source/2020/COTS/34
Department/Program
Chemistry
Additional Mentoring Department
https://cwu.studentopportunitycenter.com/2020/04/intramolecular-benzylic-sp3-c-h-oxy-functionalization-of-lactam-bearing-alkanoic-acids/
Intramolecular Benzylic sp3 C-H Oxy-functionalization of Lactam-bearing Alkanoic Acids
Ellensburg
Leishmaniasis is one of the world’s most problematic diseases in developing countries. Current medicines, including the frequently prescribed medicine, amphotericin B, have serious side effects. The existing medicines also exhibit significant parasite resistance problems. In recent years, medicinal chemists have become increasingly keen on exploring the spatial orientation of molecules. Thus, threedimensional N-heterocycles and O- heterocycles (e.g., morpholines, piperazines, and piperidines) are valuable targets for pharmaceutical companies. In this proposal, a chemoselective and stereoselective strategy for the formation of the aforementioned compounds is described. This versatile, efficient, and cost-effective process will take advantage of the more acidic nature of the benzylic carbon. Through collaborative efforts, the leishmanicidal activity of these novel compounds against Leishmania major will be tested.
https://digitalcommons.cwu.edu/source/2020/COTS/34
Faculty Mentor(s)
Timothy Beng