Assessment of the anthelmintic activity and toxicity of metabolites of Dalea pogonathera (Fabaceae)

Document Type

Article

Department or Administrative Unit

Chemistry

Publication Date

10-2022

Abstract

Dalea pogonathera A. Gray was collected as part of a project to determine if metabolites of the genus Dalea have potential for the treatment of human hookworm disease, based on earlier findings of very active materials in D. ornata. We report here the isolation, characterization, and results of ex vivo bioassays of a new chalcone pogonatheridin A (1), and three new prenylated flavanones (3, 6, and 12). The isolated known compounds, a chalcone (2), flavanones (4,5,7-11,13,14), and a flavan-3-ol (15), were also examined. Pogonatheridin A (1) reduced the survival of the adults of Ancylostoma ceylanicum hookworm by 12.5 % (50 μg/mL), while all other compounds showed very weak or no activity. The compounds were tested (50 μg/mL) for toxicity to healthy mammalian cells. Seven of them (2-8) showed > 98 % reduction in survival of splenocytes, while 1 was somewhat less toxic at 74.3 % reduction in survival. While metabolites of D. pogonathera did not show promise as potential anthelmintics for hookworm disease, the toxicity information is of interest, and the rich diversity of metabolites of Dalea spp. remains apparent.

Comments

This article was originally published in Phytochemistry Letters. The full-text article from the publisher can be found here.

Due to copyright restrictions, this article is not available for free download from ScholarWorks @ CWU.

Journal

Phytochemistry Letters

Rights

© 2022 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

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