Document Type
Thesis
Date of Degree Completion
Spring 2010
Degree Name
Bachelor of Science
Department
Chemistry
Committee Chair
Dr. Levente Fabry-Astalos, Department of Chemistry
Second Committee Member
Dr. Gil Belofsky
Third Committee Member
Dr. Audrey D. Huerta, Director Science Honors Research Program
Abstract
Implementation of antiretroviral treatment has drastically increased both the survival and quality of life of HIV/AIDS patients. While there has been significant success using these life saving drugs, several problems have arisen during their use. Among these major setbacks included the rising incidences of resistance, low bioavailability, and an unacceptable level of toxicity. Consequently, there is an urgent need for the development and production of new inhibitory compounds with increased resistance profiles, higher bioavailability, and decreased toxicity. Recent studies have demonstrated that boron modified peptides are effective inhibitors of aspartic proteases. Furthermore, these boronated compounds have exhibited dual-inhibition along with a high affinity toward both wild-type and mutant strains of the enzyme HIV-1 protease. For these reasons, we are synthesizing novel borinic acids designed to demonstrate both competitive and associative inhibitory action toward HIV-1 protease.
Recommended Citation
Clayton, Donald Ray III, "Synthesis of Novel Borinic Acids as Potential HIV-1 Protease Inhibitors" (2010). Undergraduate Honors Theses. 68.
https://digitalcommons.cwu.edu/undergrad_hontheses/68
Comments
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