Document Type
Thesis
Date of Degree Completion
Spring 2007
Degree Name
Bachelor of Science
Department
Chemistry
Committee Chair
Dr. Levente Fabry-Astalos, Department of Chemistry
Second Committee Member
Dr. Andrew A. Piacsek, Science Honors Research Program Director
Abstract
Although current HIV-1 protease inhibitors on the market show high specificity, a number of side effects can result from their administration. Furthermore, quick drug resistance is developed due to mutations of the protease. Consequently, there exists a great and urgent need for the development of a novel HIV-1 protease inhibitors that have less toxicity, greater bioavailability, and exhibit distinct resistance profiles. Recent studies have shown that borinic acid HIV-1 protease inhibitors, which can act both associatively and competitively, have a higher affinity for HIV-1 protease variants than compounds that are strictly transition state analogs. Furthermore, such inhibitors were found to be potent at lower concentrations than non-boronated protease inhibitors. The steps taken toward the synthesis of three novel potential borinic acid HIV-1 protease inhibitors are described.
Recommended Citation
Heer, Tajinder, "Synthesis Towards Novel Boron Modified Polypeptides as Potential HIV-1 Protease Inhibitors" (2007). Undergraduate Honors Theses. 78.
https://digitalcommons.cwu.edu/undergrad_hontheses/78
Comments
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