Document Type
Thesis
Date of Degree Completion
Spring 2008
Degree Name
Bachelor of Science
Department
Chemistry
Committee Chair
Dr. Levente Fabry-Astalos, Department of Chemistry
Second Committee Member
Dr. JoAnn Peters
Third Committee Member
Dr. Andrew A. Piacsek, Science Honors Research Program
Abstract
HIV/ AIDS has affected about 40 million people. One type of drug that is used to treat HIV/AIDS is a protease inhibitor. HIV-I protease is an enzyme responsible for the release of mature HIV viral particles in the body. HIV-I protease eventually becomes resistant to the inhibitors that are used as drugs and new inhibitors are needed. This research builds on a previous research effort, in which structures for HIV -1 protease inhibitors were designed using molecular modeling methods, including neural networks. These inhibitors were designed to possess better inhibitory properties, and possibly have increased bioavailability and less toxicity than the inhibitors currently in use. These novel structures are currently being synthesized using known methodologies; their inhibitory values will be determined by outside collaborators and then compared to inhibitory values predicted by the neural networks used to design them. We hope that these compounds will become lead compounds for further drug discovery for HIV/ AIDS.
Recommended Citation
Nye, Jesse Lee, "Synthesis of 5,6 Dihydropyran-2-Ones as Potential Inhibitors of HIV-1 Protease" (2008). Undergraduate Honors Theses. 93.
https://digitalcommons.cwu.edu/undergrad_hontheses/93
Comments
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