Autonomic Function Recovery and Physical Activity Levels in Post-COVID-19 Young Adults after Immunization: An Observational Follow-Up Case-Control Study
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Nutrition Exercise and Health Sciences
Coronavirus disease 2019 (COVID-19) has detrimental multi-system consequences. Symptoms may appear during the acute phase of infection, but the literature on long-term recovery of young adults after mild to moderate infection is lacking. Heart rate variability (HRV) allows for the observation of autonomic nervous system (ANS) modulation post-SARS-CoV-2 infection. Since physical activity (PA) can help improve ANS modulation, investigating factors that can influence HRV outcomes after COVID-19 is essential to advancements in care and intervention strategies. Clinicians may use this research to aid in the development of non-medication interventions. At baseline, 18 control (CT) and 20 post-COVID-19 (PCOV) participants were observed where general anamnesis was performed, followed by HRV and PA assessment. Thus, 10 CT and 7 PCOV subjects returned for follow-up (FU) evaluation 6 weeks after complete immunization (two doses) and assessments were repeated. Over the follow-up period, a decrease in sympathetic (SNS) activity (mean heart rate: p = 0.0024, CI = −24.67–−3.26; SNS index: p = 0.0068, CI = −2.50–−0.32) and increase in parasympathetic (PNS) activity (mean RR: p = 0.0097, CI = 33.72–225.51; PNS index: p = 0.0091, CI = −0.20–1.47) were observed. At follow-up, HRV was not different between groups (p > 0.05). Additionally, no differences were observed in PA between moments and groups. This study provides evidence of ANS recovery after SARS-CoV-2 insult in young adults over a follow-up period, independent of changes in PA.
Freire, A. P. C. F., Amin, S., Lira, F. S., Morano, A. E. von A., Pereira, T., Coelho-E-Silva, M.-J., Caseiro, A., Christofaro, D. G. D., Dos Santos, V. R., Júnior, O. M., Pinho, R. A., & Silva, B. S. de A. (2023). Autonomic function recovery and physical activity levels in post-covid-19 young adults after immunization: An observational follow-up case-control study. International Journal of Environmental Research and Public Health, 20(3), 2251. https://doi.org/10.3390/ijerph20032251
International Journal of Environmental Research and Public Health
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