One-shot access to isoquinolone and (hetero)izidinone architectures using cyclic α-chloro eneformamides and cyclic anhydrides

Document Type

Article

Department or Administrative Unit

Chemistry

Publication Date

3-18-2019

Abstract

Functionalized izidinones and isoquinolones are commonplace motifs in bioactive molecules. Here, we describe a direct and modular approach to [6,n] and [7,n]-1-azabicyclic unsaturated lactams, most of which bear at least one endocyclic heteroatom. A site-selective hexannulation reaction between cyclic α-chloro eneformamides and cyclic anhydrides is implicated. The scope of the anhydride component in a Castagnoli–Cushman reaction has been extended beyond 5-, 6-, and 7-membered rings.

Comments

This article was originally published in New Journal of Chemistry. The full-text article from the publisher can be found here.

Due to copyright restrictions, this article is not available for free download from ScholarWorks @ CWU.

Journal

New Journal of Chemistry

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