Studies Toward the Total Synthesis of Clavatadine A
Document Type
Oral Presentation
Campus where you would like to present
SURC 202
Start Date
17-5-2012
End Date
17-5-2012
Abstract
Clavatadine A, recently isolated from the marine sponge Suberea clavata, is a specific and potent inhibitor of factor XIa. Factor XIa is a component of the coagulation cascade required for the formation of blood clots and is a potential target for treatment of cardiovascular disease. Our efforts to complete the first total synthesis of clavatadine A feature the carbamoylation of a phenol, prepared by dibromination of homogentisic acid lactone, and an azidoisocyanate, derived from ethyl 5-bromovalerate. From our advanced carbamate intermediate, we envision completing the synthesis of clavatadine A by guanylation and lactone hydrolysis.
Recommended Citation
Conn, Stephanie; Vreeland, Shannon; and Wexler, Alexandra, "Studies Toward the Total Synthesis of Clavatadine A" (2012). Symposium Of University Research and Creative Expression (SOURCE). 86.
https://digitalcommons.cwu.edu/source/2012/oralpresentations/86
Additional Mentoring Department
Chemistry
Studies Toward the Total Synthesis of Clavatadine A
SURC 202
Clavatadine A, recently isolated from the marine sponge Suberea clavata, is a specific and potent inhibitor of factor XIa. Factor XIa is a component of the coagulation cascade required for the formation of blood clots and is a potential target for treatment of cardiovascular disease. Our efforts to complete the first total synthesis of clavatadine A feature the carbamoylation of a phenol, prepared by dibromination of homogentisic acid lactone, and an azidoisocyanate, derived from ethyl 5-bromovalerate. From our advanced carbamate intermediate, we envision completing the synthesis of clavatadine A by guanylation and lactone hydrolysis.
Faculty Mentor(s)
Stephen Chamberland