Carbonaceous Nanoparticle Toxicity as a Function of Ferrous Iron Content

Presenter Information

Daniel Hinz
Hsiang Teng
Hoi Ting

Document Type

Oral Presentation

Campus where you would like to present

SURC Ballroom C/D

Start Date

16-5-2013

End Date

16-5-2013

Abstract

Experiments on mitochondria indicate that the toxicity of atmospheric nanoparticles correlates with both ferrous iron (Fe(II)) and anthracene concentrations in collected ultrafine particles (UFP). To further understand underlying chemical mechanisms responsible for this detrimental effect, UFPs and carbonaceous nanoparticles are investigated under near physiological conditions while analyzing Fe(II) and the most prevalent oxidative species hydrogen peroxide (H2O2). Realistic concentrations of Fe(II) at sub-nanomolar and H2O2 at nanomolar levels are quantified using flow injection analysis (FIA) with chemiluminescence. Results from this study will allow for better pinpointing of the main culprit in the toxicity of inhalable carbonaceous particles that are emitted from the incomplete combustion of fossil fuel. Results have shown in particular that in the presence of a biological electron donor, such as ascorbate, hydrogen peroxide is produced under physiological conditions.

Poster Number

50

Faculty Mentor(s)

Anne Johansen

Additional Mentoring Department

Chemistry

This document is currently not available here.

Share

COinS
 
May 16th, 8:20 AM May 16th, 10:50 AM

Carbonaceous Nanoparticle Toxicity as a Function of Ferrous Iron Content

SURC Ballroom C/D

Experiments on mitochondria indicate that the toxicity of atmospheric nanoparticles correlates with both ferrous iron (Fe(II)) and anthracene concentrations in collected ultrafine particles (UFP). To further understand underlying chemical mechanisms responsible for this detrimental effect, UFPs and carbonaceous nanoparticles are investigated under near physiological conditions while analyzing Fe(II) and the most prevalent oxidative species hydrogen peroxide (H2O2). Realistic concentrations of Fe(II) at sub-nanomolar and H2O2 at nanomolar levels are quantified using flow injection analysis (FIA) with chemiluminescence. Results from this study will allow for better pinpointing of the main culprit in the toxicity of inhalable carbonaceous particles that are emitted from the incomplete combustion of fossil fuel. Results have shown in particular that in the presence of a biological electron donor, such as ascorbate, hydrogen peroxide is produced under physiological conditions.