Sustainable Synthesis of Pharmaceutically Pertinent Lactones by Intramolecular sp3 α-C–H Oxygenation of Amido Acids
Document Type
Poster
Campus where you would like to present
Ellensburg
Event Website
https://digitalcommons.cwu.edu/source
Start Date
18-5-2020
Abstract
Climate change is a daunting predicament the world has found itself in, leading to an added pressure on chemists to synthesize products in a manner that is not harmful to the environment. This is known as green chemistry. A green chemistry technique that utilizes C-H bonds is desirable considering that carbon and hydrogen are the most abundant elements in organic molecules. We herein propose a sustainable, cost-effective, and selective carbon-oxygen bond forming lactonization (production of a cyclic ester) using amido acids. The only byproduct of the reaction will be molecular hydrogen, which in turn will be collected and used as clean fuel, thus, rendering the process environmentally benign. Such a synthesis of oxygencontaining cyclic compounds is of great importance to pharmaceutical companies since they have beneficial biological activities. Through collaborative efforts, the produced lactones will be screened for potential bioactivity on G-protein coupled receptors (GPCRs).
Recommended Citation
Shearer, Victoria, "Sustainable Synthesis of Pharmaceutically Pertinent Lactones by Intramolecular sp3 α-C–H Oxygenation of Amido Acids" (2020). Symposium Of University Research and Creative Expression (SOURCE). 38.
https://digitalcommons.cwu.edu/source/2020/COTS/38
Department/Program
Chemistry
Additional Mentoring Department
https://cwu.studentopportunitycenter.com/2020/04/voice-over-poste/
Sustainable Synthesis of Pharmaceutically Pertinent Lactones by Intramolecular sp3 α-C–H Oxygenation of Amido Acids
Ellensburg
Climate change is a daunting predicament the world has found itself in, leading to an added pressure on chemists to synthesize products in a manner that is not harmful to the environment. This is known as green chemistry. A green chemistry technique that utilizes C-H bonds is desirable considering that carbon and hydrogen are the most abundant elements in organic molecules. We herein propose a sustainable, cost-effective, and selective carbon-oxygen bond forming lactonization (production of a cyclic ester) using amido acids. The only byproduct of the reaction will be molecular hydrogen, which in turn will be collected and used as clean fuel, thus, rendering the process environmentally benign. Such a synthesis of oxygencontaining cyclic compounds is of great importance to pharmaceutical companies since they have beneficial biological activities. Through collaborative efforts, the produced lactones will be screened for potential bioactivity on G-protein coupled receptors (GPCRs).
https://digitalcommons.cwu.edu/source/2020/COTS/38
Faculty Mentor(s)
Timothy Beng