Synthesis of Boron-Containing Structural Building Blocks For Use in Potential Protease Enzyme Inhibitors
Document Type
Poster
Campus where you would like to present
Ellensburg
Event Website
https://digitalcommons.cwu.edu/source
Start Date
18-5-2020
Abstract
1,3-Azaborines have good potential to function as dual-mode, both associative and competitive, inhibitors of protease enzymes, which are involved in the development of several disease states, including the Human Immunodeficiency Virus (HIV) infection/acquired immunodeficiency syndrome (AIDS), malaria, Alzheimer’s, and some forms of cancer. In our syntheses boron-modified amino acids (including boronated phenylalanine and isoleucine) are being developed as chemical precursors, which are then incorporated into larger boronates in order to obtain the biologically relevant 1,3-azaborines. The target 1,3-azaborines were designed to complement the structure of the enzyme’s chiral active site. In our synthetic schemes pinacol and (1R,2R)-1,2-dicyclohexyl-1,2-ethanediol are both used as protecting groups, while (1R,2R)-1,2-dicyclohexyl-1,2-ethanediol is also used as a chiral director. The target boronates have the potential for greater affinity towards protease enzymes, dual-mode of action, increased bioavailability, and fewer adverse side effects. Many studies have shown that boron-modified inhibitors have a higher inhibitory affinity for protease enzymes than the corresponding non-boron analogs. The non-boron analogs are experiencing high resistance rates, low bioavailability, and patient noncompliance due to adverse side effects. As a result, there is a higher demand for the development of new compounds to combat these diseases.
Recommended Citation
Wilson, Andrew; Huber, Hannah; and Dawson, Sean, "Synthesis of Boron-Containing Structural Building Blocks For Use in Potential Protease Enzyme Inhibitors" (2020). Symposium Of University Research and Creative Expression (SOURCE). 40.
https://digitalcommons.cwu.edu/source/2020/COTS/40
Department/Program
Chemistry
Additional Mentoring Department
https://cwu.studentopportunitycenter.com/2020/04/synthesis-of-boron-containing-structural-building-blocks-for-use-in-potential-protease-enzyme-inhibitors/
Synthesis of Boron-Containing Structural Building Blocks For Use in Potential Protease Enzyme Inhibitors
Ellensburg
1,3-Azaborines have good potential to function as dual-mode, both associative and competitive, inhibitors of protease enzymes, which are involved in the development of several disease states, including the Human Immunodeficiency Virus (HIV) infection/acquired immunodeficiency syndrome (AIDS), malaria, Alzheimer’s, and some forms of cancer. In our syntheses boron-modified amino acids (including boronated phenylalanine and isoleucine) are being developed as chemical precursors, which are then incorporated into larger boronates in order to obtain the biologically relevant 1,3-azaborines. The target 1,3-azaborines were designed to complement the structure of the enzyme’s chiral active site. In our synthetic schemes pinacol and (1R,2R)-1,2-dicyclohexyl-1,2-ethanediol are both used as protecting groups, while (1R,2R)-1,2-dicyclohexyl-1,2-ethanediol is also used as a chiral director. The target boronates have the potential for greater affinity towards protease enzymes, dual-mode of action, increased bioavailability, and fewer adverse side effects. Many studies have shown that boron-modified inhibitors have a higher inhibitory affinity for protease enzymes than the corresponding non-boron analogs. The non-boron analogs are experiencing high resistance rates, low bioavailability, and patient noncompliance due to adverse side effects. As a result, there is a higher demand for the development of new compounds to combat these diseases.
https://digitalcommons.cwu.edu/source/2020/COTS/40
Faculty Mentor(s)
Levente Fabry