Title

Sustainable Synthesis of Pharmaceutically Pertinent Lactones by Intramolecular sp3 α-C–H Oxygenation of Amido Acids

Document Type

Poster

Campus where you would like to present

Ellensburg

Event Website

https://digitalcommons.cwu.edu/source

Start Date

18-5-2020

Abstract

Climate change is a daunting predicament the world has found itself in, leading to an added pressure on chemists to synthesize products in a manner that is not harmful to the environment. This is known as green chemistry. A green chemistry technique that utilizes C-H bonds is desirable considering that carbon and hydrogen are the most abundant elements in organic molecules. We herein propose a sustainable, cost-effective, and selective carbon-oxygen bond forming lactonization (production of a cyclic ester) using amido acids. The only byproduct of the reaction will be molecular hydrogen, which in turn will be collected and used as clean fuel, thus, rendering the process environmentally benign. Such a synthesis of oxygencontaining cyclic compounds is of great importance to pharmaceutical companies since they have beneficial biological activities. Through collaborative efforts, the produced lactones will be screened for potential bioactivity on G-protein coupled receptors (GPCRs).

Faculty Mentor(s)

Timothy Beng

Department/Program

Chemistry

Additional Mentoring Department

https://cwu.studentopportunitycenter.com/2020/04/voice-over-poste/

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May 18th, 12:00 PM

Sustainable Synthesis of Pharmaceutically Pertinent Lactones by Intramolecular sp3 α-C–H Oxygenation of Amido Acids

Ellensburg

Climate change is a daunting predicament the world has found itself in, leading to an added pressure on chemists to synthesize products in a manner that is not harmful to the environment. This is known as green chemistry. A green chemistry technique that utilizes C-H bonds is desirable considering that carbon and hydrogen are the most abundant elements in organic molecules. We herein propose a sustainable, cost-effective, and selective carbon-oxygen bond forming lactonization (production of a cyclic ester) using amido acids. The only byproduct of the reaction will be molecular hydrogen, which in turn will be collected and used as clean fuel, thus, rendering the process environmentally benign. Such a synthesis of oxygencontaining cyclic compounds is of great importance to pharmaceutical companies since they have beneficial biological activities. Through collaborative efforts, the produced lactones will be screened for potential bioactivity on G-protein coupled receptors (GPCRs).

https://digitalcommons.cwu.edu/source/2020/COTS/38