Document Type
Thesis
Date of Degree Completion
Spring 2012
Degree Name
Bachelor of Science
Department
Chemistry
Committee Chair
Dr. Levente Fabry-Astalos, Department of Chemistry
Second Committee Member
Dr. Stephen Chamberland, Department of Chemistry
Third Committee Member
Dr. Audrey D. Huerta, Director Science Honors Research Program
Abstract
Currently more than 40 million people worldwide are suffering from HIV/AIDS. Despite the billions of dollars that have been put into research and development of HIV drugs, a cure has not been discovered. Protease inhibitors are a class of drugs that slow the progression of the disease. This research aims to create five boronated amino acid analogs that will be used in future synthesis of potential HIV-1 protease inhibitors. The purpose of including these amino acid analogs in potential inhibitors is to increase drug bioavailability by mimicking an amino acid structure. The amino acid analog also may help to create a stronger binding affinity for the active site of the HIV-1 protease, and increase structural rigidity. The combination of these factors has the desired outcome of increasing drug bioavailability, which reduces the required dosages given to patients, and therefore reduces toxicity risk.
Recommended Citation
Faulkner, Andrea, "Towards the Synthesis of (S)-(Acetamido9p-tolyl)methyl) Boronic Acid and its Analogs as Precursors for Potential Boronated HIV-1 Protease Inhibitors" (2012). Undergraduate Honors Theses. 66.
https://digitalcommons.cwu.edu/undergrad_hontheses/66
Comments
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