Document Type
Thesis
Date of Degree Completion
Spring 2012
Degree Name
Bachelor of Science
Department
Chemistry
Committee Chair
Dr. Stephen Chamberland, Department of Chemistry
Second Committee Member
Dr. Todd Kroll, Department of Chemistry
Third Committee Member
Dr. Audrey D. Huerta, Director Science Honors Research Program
Abstract
Cardiovascular disease is a leading cause of death in humans. one cause of cardiovascular disease is excessive clot formation, or thrombosis. Although it can be fatal, thrombosis can be prevented or treated using inhibitors that target specific proteins in the blood coagulation pathway. Nevertheless, few targeted inhibitors of thrombosis have been reported. Clavatadine A is a specific and potent Factor XIa inhibitor (IC501.3uM) that was recently isolated from the Australian marine sponge Suberea clavata. Here, we report the completion of the synthesis for the synthetic stating materials, a dibrominated derivative of homogentisic acid lactone and an azidoiscyanate. We also report the completion of an addition reaction with an axidoisocyanate and a dibrominated derivative of homogentisic acid lactone to produce an advanced carbamate intermediate.
Recommended Citation
Conn, Stephanie, "Studies Toward the Total Synthesis of Clavatadine A" (2012). Undergraduate Honors Theses. 67.
https://digitalcommons.cwu.edu/undergrad_hontheses/67
Comments
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