Document Type
Thesis
Date of Degree Completion
Spring 2008
Degree Name
Bachelor of Science
Department
Chemistry
Committee Chair
Dr. Levente Fabry-Astalos, Department of Chemistry
Second Committee Member
Dr. JoAnn Peters
Third Committee Member
Dr. Andrew A. Piacsek, Science Honors Research Program
Abstract
Drug discovery has resulted in many life-saving therapies, making a great impact on modem medicine and the human condition. Even though new therapies are available many drugs are highly susceptible to resistance development, have poor bioavailability, and some of them are toxic. HIV-I protease inhibitors presently on the market show high specificity but have low bioavailability and high toxicity. Furthermore, the available drugs have a very low affinity for mutant forms of HIV -1 protease. Recent studies have shown that boronated HIV-I protease inhibitors, which demonstrate both competitive and associative inhibition, have a higher affinity for HIV-I protease at lower concentrations than their corresponding carbon analogs and also inhibit a mutant form of HIV-I protease. In this study nine novel I,3-azaborine type of heterocycles are being synthesized. Their biological characteristics will be analyzed and compared with other inhibitors to determine their effectiveness as potential novel anti-HIV drugs.
Recommended Citation
Blackmore, Amanda, "Synthesis Towards Novel 1,3-Azaborine Heterocycles as Potential Dual-Mode HIV-1 Protease Inhibitors" (2008). Undergraduate Honors Theses. 90.
https://digitalcommons.cwu.edu/undergrad_hontheses/90
Comments
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