Investigation of Salvia columbariae for Dopamine Receptor Related Activity
Document Type
Oral Presentation
Campus where you would like to present
SURC Ballroom A
Start Date
17-5-2012
End Date
17-5-2012
Abstract
The plant Salvia columbariae is native to Western California, Utah, and ranges south to Northern Mexico. It has been used historically by indigenous peoples as a dietary supplement and a medicinal herb. A relative of S. columbariae is S. divinorum which is used as a recreational drug and has known opioid receptor binding activity. Prior work with extracts of S. columbariae revealed diterpenes to be present in the plant. A large scale extraction has been done and the crude extract does exhibit moderate dopamine receptor binding activity. We have used techniques such as vacuum liquid chromatography (VLC) and Sephadex LH-20 to purify, and thin-layer chromatography (TLC) for ongoing analysis. Future plans are to further refine these materials to purity, and to get more biological testing done. We hope to see if there is dopamine receptor activity in pure compounds for potential applications to Parkinson’s disease, for which there is currently no cure.
Recommended Citation
Bell, Logan, "Investigation of Salvia columbariae for Dopamine Receptor Related Activity" (2012). Symposium Of University Research and Creative Expression (SOURCE). 13.
https://digitalcommons.cwu.edu/source/2012/posters/13
Poster Number
21
Additional Mentoring Department
Chemistry
Investigation of Salvia columbariae for Dopamine Receptor Related Activity
SURC Ballroom A
The plant Salvia columbariae is native to Western California, Utah, and ranges south to Northern Mexico. It has been used historically by indigenous peoples as a dietary supplement and a medicinal herb. A relative of S. columbariae is S. divinorum which is used as a recreational drug and has known opioid receptor binding activity. Prior work with extracts of S. columbariae revealed diterpenes to be present in the plant. A large scale extraction has been done and the crude extract does exhibit moderate dopamine receptor binding activity. We have used techniques such as vacuum liquid chromatography (VLC) and Sephadex LH-20 to purify, and thin-layer chromatography (TLC) for ongoing analysis. Future plans are to further refine these materials to purity, and to get more biological testing done. We hope to see if there is dopamine receptor activity in pure compounds for potential applications to Parkinson’s disease, for which there is currently no cure.
Faculty Mentor(s)
Gil Belofsky